Specular microscopy assessment of the human corneal endothelium (CE) in Fuchs' dystrophy is challenging due to the presence of dark image regions called guttae. This paper proposes a UNet-based segmentation approach that requires minimal post-processing and achieves reliable CE morphometric assessment and guttae identification across all degrees of Fuchs' dystrophy. We cast the segmentation problem as a regression task of the cell and gutta signed distance maps instead of a pixel-level classification task as typically done with UNets. Compared to the conventional UNet classification approach, the distance-map regression approach converges faster in clinically relevant parameters. It also produces morphometric parameters that agree with the manually-segmented ground-truth data, namely the average cell density difference of -41.9 cells/mm2 (95% confidence interval (CI) [-306.2, 222.5]) and the average difference of mean cell area of 14.8 um2 (95% CI [-41.9, 71.5]). These results suggest a promising alternative for CE assessment.

自由格式介绍是在任意二进制掩码指定的区域中向图像中添加新内容的任务。大多数现有方法训练了一定的面具分布，这将其概括能力限制为看不见的掩模类型。此外，通过像素和知觉损失的训练通常会导致对缺失区域的简单质地扩展，而不是语义上有意义的一代。在这项工作中，我们提出重新启动：基于deno的扩散概率模型（DDPM）的内部介入方法，甚至适用于极端掩模。我们采用预定的无条件DDPM作为生成先验。为了调节生成过程，我们仅通过使用给定的图像信息对未掩盖的区域进行采样来改变反向扩散迭代。由于该技术不会修改或调节原始DDPM网络本身，因此该模型可为任何填充形式产生高质量和不同的输出图像。我们使用标准面具和极端口罩验证面部和通用图像的方法。重新粉刷优于最先进的自动回归，而GAN的方法至少在六个面具分布中进行了五个。 github存储库：git.io/repaint

Uncertainty quantification is crucial to inverse problems, as it could provide decision-makers with valuable information about the inversion results. For example, seismic inversion is a notoriously ill-posed inverse problem due to the band-limited and noisy nature of seismic data. It is therefore of paramount importance to quantify the uncertainties associated to the inversion process to ease the subsequent interpretation and decision making processes. Within this framework of reference, sampling from a target posterior provides a fundamental approach to quantifying the uncertainty in seismic inversion. However, selecting appropriate prior information in a probabilistic inversion is crucial, yet non-trivial, as it influences the ability of a sampling-based inference in providing geological realism in the posterior samples. To overcome such limitations, we present a regularized variational inference framework that performs posterior inference by implicitly regularizing the Kullback-Leibler divergence loss with a CNN-based denoiser by means of the Plug-and-Play methods. We call this new algorithm Plug-and-Play Stein Variational Gradient Descent (PnP-SVGD) and demonstrate its ability in producing high-resolution, trustworthy samples representative of the subsurface structures, which we argue could be used for post-inference tasks such as reservoir modelling and history matching. To validate the proposed method, numerical tests are performed on both synthetic and field post-stack seismic data.

Biometrics is the science of identifying an individual based on their intrinsic anatomical or behavioural characteristics, such as fingerprints, face, iris, gait, and voice. Iris recognition is one of the most successful methods because it exploits the rich texture of the human iris, which is unique even for twins and does not degrade with age. Modern approaches to iris recognition utilize deep learning to segment the valid portion of the iris from the rest of the eye, so it can then be encoded, stored and compared. This paper aims to improve the accuracy of iris semantic segmentation systems by introducing a novel data augmentation technique. Our method can transform an iris image with a certain dilation level into any desired dilation level, thus augmenting the variability and number of training examples from a small dataset. The proposed method is fast and does not require training. The results indicate that our data augmentation method can improve segmentation accuracy up to 15% for images with high pupil dilation, which creates a more reliable iris recognition pipeline, even under extreme dilation.

Social insects such as ants communicate via pheromones which allows them to coordinate their activity and solve complex tasks as a swarm, e.g. foraging for food. This behaviour was shaped through evolutionary processes. In computational models, self-coordination in swarms has been implemented using probabilistic or action rules to shape the decision of each agent and the collective behaviour. However, manual tuned decision rules may limit the behaviour of the swarm. In this work we investigate the emergence of self-coordination and communication in evolved swarms without defining any rule. We evolve a swarm of agents representing an ant colony. We use a genetic algorithm to optimize a spiking neural network (SNN) which serves as an artificial brain to control the behaviour of each agent. The goal of the colony is to find optimal ways to forage for food in the shortest amount of time. In the evolutionary phase, the ants are able to learn to collaborate by depositing pheromone near food piles and near the nest to guide its cohorts. The pheromone usage is not encoded into the network; instead, this behaviour is established through the optimization procedure. We observe that pheromone-based communication enables the ants to perform better in comparison to colonies where communication did not emerge. We assess the foraging performance by comparing the SNN based model to a rule based system. Our results show that the SNN based model can complete the foraging task more efficiently in a shorter time. Our approach illustrates that even in the absence of pre-defined rules, self coordination via pheromone emerges as a result of the network optimization. This work serves as a proof of concept for the possibility of creating complex applications utilizing SNNs as underlying architectures for multi-agent interactions where communication and self-coordination is desired.

We introduce M-VADER: a diffusion model (DM) for image generation where the output can be specified using arbitrary combinations of images and text. We show how M-VADER enables the generation of images specified using combinations of image and text, and combinations of multiple images. Previously, a number of successful DM image generation algorithms have been introduced that make it possible to specify the output image using a text prompt. Inspired by the success of those models, and led by the notion that language was already developed to describe the elements of visual contexts that humans find most important, we introduce an embedding model closely related to a vision-language model. Specifically, we introduce the embedding model S-MAGMA: a 13 billion parameter multimodal decoder combining components from an autoregressive vision-language model MAGMA and biases finetuned for semantic search.

Knowledge graphs, modeling multi-relational data, improve numerous applications such as question answering or graph logical reasoning. Many graph neural networks for such data emerged recently, often outperforming shallow architectures. However, the design of such multi-relational graph neural networks is ad-hoc, driven mainly by intuition and empirical insights. Up to now, their expressivity, their relation to each other, and their (practical) learning performance is poorly understood. Here, we initiate the study of deriving a more principled understanding of multi-relational graph neural networks. Namely, we investigate the limitations in the expressive power of the well-known Relational GCN and Compositional GCN architectures and shed some light on their practical learning performance. By aligning both architectures with a suitable version of the Weisfeiler-Leman test, we establish under which conditions both models have the same expressive power in distinguishing non-isomorphic (multi-relational) graphs or vertices with different structural roles. Further, by leveraging recent progress in designing expressive graph neural networks, we introduce the $k$-RN architecture that provably overcomes the expressiveness limitations of the above two architectures. Empirically, we confirm our theoretical findings in a vertex classification setting over small and large multi-relational graphs.

Reinforcement Learning has emerged as a strong alternative to solve optimization tasks efficiently. The use of these algorithms highly depends on the feedback signals provided by the environment in charge of informing about how good (or bad) the decisions made by the learned agent are. Unfortunately, in a broad range of problems the design of a good reward function is not trivial, so in such cases sparse reward signals are instead adopted. The lack of a dense reward function poses new challenges, mostly related to exploration. Imitation Learning has addressed those problems by leveraging demonstrations from experts. In the absence of an expert (and its subsequent demonstrations), an option is to prioritize well-suited exploration experiences collected by the agent in order to bootstrap its learning process with good exploration behaviors. However, this solution highly depends on the ability of the agent to discover such trajectories in the early stages of its learning process. To tackle this issue, we propose to combine imitation learning with intrinsic motivation, two of the most widely adopted techniques to address problems with sparse reward. In this work intrinsic motivation is used to encourage the agent to explore the environment based on its curiosity, whereas imitation learning allows repeating the most promising experiences to accelerate the learning process. This combination is shown to yield an improved performance and better generalization in procedurally-generated environments, outperforming previously reported self-imitation learning methods and achieving equal or better sample efficiency with respect to intrinsic motivation in isolation.

Counterfactual Explanations are becoming a de-facto standard in post-hoc interpretable machine learning. For a given classifier and an instance classified in an undesired class, its counterfactual explanation corresponds to small perturbations of that instance that allows changing the classification outcome. This work aims to leverage Counterfactual Explanations to detect the important decision boundaries of a pre-trained black-box model. This information is used to build a supervised discretization of the features in the dataset with a tunable granularity. Using the discretized dataset, a smaller, therefore more interpretable Decision Tree can be trained, which, in addition, enhances the stability and robustness of the baseline Decision Tree. Numerical results on real-world datasets show the effectiveness of the approach in terms of accuracy and sparsity compared to the baseline Decision Tree.

Double-blind peer review is considered a pillar of academic research because it is perceived to ensure a fair, unbiased, and fact-centered scientific discussion. Yet, experienced researchers can often correctly guess from which research group an anonymous submission originates, biasing the peer-review process. In this work, we present a transformer-based, neural-network architecture that only uses the text content and the author names in the bibliography to atttribute an anonymous manuscript to an author. To train and evaluate our method, we created the largest authorship-identification dataset to date. It leverages all research papers publicly available on arXiv amounting to over 2 million manuscripts. In arXiv-subsets with up to 2,000 different authors, our method achieves an unprecedented authorship attribution accuracy, where up to 95% of papers are attributed correctly. Thanks to our method, we are not only able to predict the author of an anonymous work but we also identify weaknesses of the double-blind review process by finding the key aspects that make a paper attributable. We believe that this work gives precious insights into how a submission can remain anonymous in order to support an unbiased double-blind review process.