We present Muse, a text-to-image Transformer model that achieves state-of-the-art image generation performance while being significantly more efficient than diffusion or autoregressive models. Muse is trained on a masked modeling task in discrete token space: given the text embedding extracted from a pre-trained large language model (LLM), Muse is trained to predict randomly masked image tokens. Compared to pixel-space diffusion models, such as Imagen and DALL-E 2, Muse is significantly more efficient due to the use of discrete tokens and requiring fewer sampling iterations; compared to autoregressive models, such as Parti, Muse is more efficient due to the use of parallel decoding. The use of a pre-trained LLM enables fine-grained language understanding, translating to high-fidelity image generation and the understanding of visual concepts such as objects, their spatial relationships, pose, cardinality etc. Our 900M parameter model achieves a new SOTA on CC3M, with an FID score of 6.06. The Muse 3B parameter model achieves an FID of 7.88 on zero-shot COCO evaluation, along with a CLIP score of 0.32. Muse also directly enables a number of image editing applications without the need to fine-tune or invert the model: inpainting, outpainting, and mask-free editing. More results are available at https://muse-model.github.io

To improve the performance of the dual-encoder retriever, one effective approach is knowledge distillation from the cross-encoder ranker. Existing works construct the candidate passages following the supervised learning setting where a query is paired with a positive passage and a batch of negatives. However, through empirical observation, we find that even the hard negatives from advanced methods are still too trivial for the teacher to distinguish, preventing the teacher from transferring abundant dark knowledge to the student through its soft label. To alleviate this issue, we propose ADAM, a knowledge distillation framework that can better transfer the dark knowledge held in the teacher with Adaptive Dark exAMples. Different from previous works that only rely on one positive and hard negatives as candidate passages, we create dark examples that all have moderate relevance to the query through mixing-up and masking in discrete space. Furthermore, as the quality of knowledge held in different training instances varies as measured by the teacher's confidence score, we propose a self-paced distillation strategy that adaptively concentrates on a subset of high-quality instances to conduct our dark-example-based knowledge distillation to help the student learn better. We conduct experiments on two widely-used benchmarks and verify the effectiveness of our method.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Neural networks (NN) play a central role in modern Artificial intelligence (AI) technology and has been successfully used in areas such as natural language processing and image recognition. While majority of NN applications focus on prediction and classification, there are increasing interests in studying statistical inference of neural networks. The study of NN statistical inference can enhance our understanding of NN statistical proprieties. Moreover, it can facilitate the NN-based hypothesis testing that can be applied to hypothesis-driven clinical and biomedical research. In this paper, we propose a sieve quasi-likelihood ratio test based on NN with one hidden layer for testing complex associations. The test statistic has asymptotic chi-squared distribution, and therefore it is computationally efficient and easy for implementation in real data analysis. The validity of the asymptotic distribution is investigated via simulations. Finally, we demonstrate the use of the proposed test by performing a genetic association analysis of the sequencing data from Alzheimer's Disease Neuroimaging Initiative (ADNI).

We introduce the MAsked Generative VIdeo Transformer, MAGVIT, to tackle various video synthesis tasks with a single model. We introduce a 3D tokenizer to quantize a video into spatial-temporal visual tokens and propose an embedding method for masked video token modeling to facilitate multi-task learning. We conduct extensive experiments to demonstrate the quality, efficiency, and flexibility of MAGVIT. Our experiments show that (i) MAGVIT performs favorably against state-of-the-art approaches and establishes the best-published FVD on three video generation benchmarks, including the challenging Kinetics-600. (ii) MAGVIT outperforms existing methods in inference time by two orders of magnitude against diffusion models and by 60x against autoregressive models. (iii) A single MAGVIT model supports ten diverse generation tasks and generalizes across videos from different visual domains. The source code and trained models will be released to the public at https://magvit.cs.cmu.edu.

Objective: We aim to develop an open-source natural language processing (NLP) package, SODA (i.e., SOcial DeterminAnts), with pre-trained transformer models to extract social determinants of health (SDoH) for cancer patients, examine the generalizability of SODA to a new disease domain (i.e., opioid use), and evaluate the extraction rate of SDoH using cancer populations. Methods: We identified SDoH categories and attributes and developed an SDoH corpus using clinical notes from a general cancer cohort. We compared four transformer-based NLP models to extract SDoH, examined the generalizability of NLP models to a cohort of patients prescribed with opioids, and explored customization strategies to improve performance. We applied the best NLP model to extract 19 categories of SDoH from the breast (n=7,971), lung (n=11,804), and colorectal cancer (n=6,240) cohorts. Results and Conclusion: We developed a corpus of 629 cancer patients notes with annotations of 13,193 SDoH concepts/attributes from 19 categories of SDoH. The Bidirectional Encoder Representations from Transformers (BERT) model achieved the best strict/lenient F1 scores of 0.9216 and 0.9441 for SDoH concept extraction, 0.9617 and 0.9626 for linking attributes to SDoH concepts. Fine-tuning the NLP models using new annotations from opioid use patients improved the strict/lenient F1 scores from 0.8172/0.8502 to 0.8312/0.8679. The extraction rates among 19 categories of SDoH varied greatly, where 10 SDoH could be extracted from >70% of cancer patients, but 9 SDoH had a low extraction rate (<70% of cancer patients). The SODA package with pre-trained transformer models is publicly available at https://github.com/uf-hobiinformatics-lab/SDoH_SODA.

Motion prediction is highly relevant to the perception of dynamic objects and static map elements in the scenarios of autonomous driving. In this work, we propose PIP, the first end-to-end Transformer-based framework which jointly and interactively performs online mapping, object detection and motion prediction. PIP leverages map queries, agent queries and mode queries to encode the instance-wise information of map elements, agents and motion intentions, respectively. Based on the unified query representation, a differentiable multi-task interaction scheme is proposed to exploit the correlation between perception and prediction. Even without human-annotated HD map or agent's historical tracking trajectory as guidance information, PIP realizes end-to-end multi-agent motion prediction and achieves better performance than tracking-based and HD-map-based methods. PIP provides comprehensive high-level information of the driving scene (vectorized static map and dynamic objects with motion information), and contributes to the downstream planning and control. Code and models will be released for facilitating further research.

Text-guided 3D object generation aims to generate 3D objects described by user-defined captions, which paves a flexible way to visualize what we imagined. Although some works have been devoted to solving this challenging task, these works either utilize some explicit 3D representations (e.g., mesh), which lack texture and require post-processing for rendering photo-realistic views; or require individual time-consuming optimization for every single case. Here, we make the first attempt to achieve generic text-guided cross-category 3D object generation via a new 3D-TOGO model, which integrates a text-to-views generation module and a views-to-3D generation module. The text-to-views generation module is designed to generate different views of the target 3D object given an input caption. prior-guidance, caption-guidance and view contrastive learning are proposed for achieving better view-consistency and caption similarity. Meanwhile, a pixelNeRF model is adopted for the views-to-3D generation module to obtain the implicit 3D neural representation from the previously-generated views. Our 3D-TOGO model generates 3D objects in the form of the neural radiance field with good texture and requires no time-cost optimization for every single caption. Besides, 3D-TOGO can control the category, color and shape of generated 3D objects with the input caption. Extensive experiments on the largest 3D object dataset (i.e., ABO) are conducted to verify that 3D-TOGO can better generate high-quality 3D objects according to the input captions across 98 different categories, in terms of PSNR, SSIM, LPIPS and CLIP-score, compared with text-NeRF and Dreamfields.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Various depth estimation models are now widely used on many mobile and IoT devices for image segmentation, bokeh effect rendering, object tracking and many other mobile tasks. Thus, it is very crucial to have efficient and accurate depth estimation models that can run fast on low-power mobile chipsets. In this Mobile AI challenge, the target was to develop deep learning-based single image depth estimation solutions that can show a real-time performance on IoT platforms and smartphones. For this, the participants used a large-scale RGB-to-depth dataset that was collected with the ZED stereo camera capable to generated depth maps for objects located at up to 50 meters. The runtime of all models was evaluated on the Raspberry Pi 4 platform, where the developed solutions were able to generate VGA resolution depth maps at up to 27 FPS while achieving high fidelity results. All models developed in the challenge are also compatible with any Android or Linux-based mobile devices, their detailed description is provided in this paper.