在机器学习中的解释性的重要性继续增长，因为神经网络架构和它们模型的数据变得越来越复杂。当模型的输入功能变为高维时，出现独特的挑战：一方面，解释性的原则性模型可靠性方法变得过于计算昂贵;另一方面，更高效的解释性算法缺乏对普通用户的自然解释。在这项工作中，我们在高维数据上介绍了用于人类可解释的解释性的框架，由两个模块组成。首先，我们应用一个语义上有意义的潜在表示，以降低数据的原始维度，并确保其人的解释性。可以学习这些潜在的特征，例如，通过图像到图像转换明确地解散表示或隐含地解散表示，或者它们可以基于用户选择的任何可计算量。其次，我们适应福利范式以进行模型 - 无人释放能力，以在这些潜在特征上运行。这导致理论上控制和计算易解释的可解释模型解释。我们在合成数据上基准测试我们的方法，并展示其对几种图像分类任务的效果。

AI中的解释性对于模型开发，遵守规则并提供对预测的操作细微差异至关重要。 Shapley框架解释性地将模型的预测以数学上的原则和模型无话的方式对其输入特征属性。然而，福利释放性的一般实施使得一个无法维持的假设：模型的功能是不相关的。在这项工作中，我们展示了这种假设的明确缺点，并开发了两个对围绕数据歧管的福利解释性的解决方案。基于生成建模的一种解决方案提供了对数据避难所的灵活访问;另一种直接学习福利价值功能，以灵活成本提供性能和稳定性。虽然“偏流”福谢值（i）产生不正确的解释，但是（ii）隐藏对敏感属性的隐式模型依赖性，并且（iii）导致在高维数据中的解释，歧管解释性克服了这些问题。

解释AI系统是对高性能模型的发展以及由用户放置在其中的信任的基础。福利框架可解释性具有强大的普遍适用性，结合其精确，严谨的基础：它为AI解释性提供了一种常见的模型 - 不可知论性，并且唯一满足一组直观的数学公理。但是，福利值在一个重要方面过于限制：它们忽略了数据中的所有因果结构。我们介绍了一种更少的限制性框架，不对称的福利值（ASV），其严格地建立在一组公理上，适用于任何AI系统，并且足够灵活地融合已知数据所遵守的任何因果结构。我们证明ASVS可以（i）通过结合因果信息来改善模型解释，（ii）在模型预测中提供不公平歧视的明确测试，（iii）在时间序列模型中顺序增量解释，（iv）支持特征 - 无需模型再培训的选择研究。

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse images to build representations of both small-scale features (e.g., the presence of cells or blood vessels) and global properties of an image (e.g., which brain region the image comes from) is a crucial and open challenge. However, most existing datasets and benchmarks for neuroanatomy consider only a single downstream task at a time. To bridge this gap, we introduce a new dataset, annotations, and multiple downstream tasks that provide diverse ways to readout information about brain structure and architecture from the same image. Our multi-task neuroimaging benchmark (MTNeuro) is built on volumetric, micrometer-resolution X-ray microtomography images spanning a large thalamocortical section of mouse brain, encompassing multiple cortical and subcortical regions. We generated a number of different prediction challenges and evaluated several supervised and self-supervised models for brain-region prediction and pixel-level semantic segmentation of microstructures. Our experiments not only highlight the rich heterogeneity of this dataset, but also provide insights into how self-supervised approaches can be used to learn representations that capture multiple attributes of a single image and perform well on a variety of downstream tasks. Datasets, code, and pre-trained baseline models are provided at: https://mtneuro.github.io/ .

Remote sensing imagery provides comprehensive views of the Earth, where different sensors collect complementary data at different spatial scales. Large, pretrained models are commonly finetuned with imagery that is heavily augmented to mimic different conditions and scales, with the resulting models used for various tasks with imagery from a range of spatial scales. Such models overlook scale-specific information in the data. In this paper, we present Scale-MAE, a pretraining method that explicitly learns relationships between data at different, known scales throughout the pretraining process. Scale-MAE pretrains a network by masking an input image at a known input scale, where the area of the Earth covered by the image determines the scale of the ViT positional encoding, not the image resolution. Scale-MAE encodes the masked image with a standard ViT backbone, and then decodes the masked image through a bandpass filter to reconstruct low/high frequency images at lower/higher scales. We find that tasking the network with reconstructing both low/high frequency images leads to robust multiscale representations for remote sensing imagery. Scale-MAE achieves an average of a $5.0\%$ non-parametric kNN classification improvement across eight remote sensing datasets compared to current state-of-the-art and obtains a $0.9$ mIoU to $3.8$ mIoU improvement on the SpaceNet building segmentation transfer task for a range of evaluation scales.

With an ever-growing number of parameters defining increasingly complex networks, Deep Learning has led to several breakthroughs surpassing human performance. As a result, data movement for these millions of model parameters causes a growing imbalance known as the memory wall. Neuromorphic computing is an emerging paradigm that confronts this imbalance by performing computations directly in analog memories. On the software side, the sequential Backpropagation algorithm prevents efficient parallelization and thus fast convergence. A novel method, Direct Feedback Alignment, resolves inherent layer dependencies by directly passing the error from the output to each layer. At the intersection of hardware/software co-design, there is a demand for developing algorithms that are tolerable to hardware nonidealities. Therefore, this work explores the interrelationship of implementing bio-plausible learning in-situ on neuromorphic hardware, emphasizing energy, area, and latency constraints. Using the benchmarking framework DNN+NeuroSim, we investigate the impact of hardware nonidealities and quantization on algorithm performance, as well as how network topologies and algorithm-level design choices can scale latency, energy and area consumption of a chip. To the best of our knowledge, this work is the first to compare the impact of different learning algorithms on Compute-In-Memory-based hardware and vice versa. The best results achieved for accuracy remain Backpropagation-based, notably when facing hardware imperfections. Direct Feedback Alignment, on the other hand, allows for significant speedup due to parallelization, reducing training time by a factor approaching N for N-layered networks.

Artificial Intelligence (AI) has become commonplace to solve routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. We project that the gap between the number of imaging exams and the number of expert radiologist readers required to cover this increase will continue to expand, consequently introducing a demand for AI-based tools that improve the efficiency with which radiologists can comfortably interpret these exams. AI has been shown to improve efficiency in medical-image generation, processing, and interpretation, and a variety of such AI models have been developed across research labs worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. To address the barrier to clinical deployment, we have formed MONAI Consortium, an open-source community which is building standards for AI deployment in healthcare institutions, and developing tools and infrastructure to facilitate their implementation. This report represents several years of weekly discussions and hands-on problem solving experience by groups of industry experts and clinicians in the MONAI Consortium. We identify barriers between AI-model development in research labs and subsequent clinical deployment and propose solutions. Our report provides guidance on processes which take an imaging AI model from development to clinical implementation in a healthcare institution. We discuss various AI integration points in a clinical Radiology workflow. We also present a taxonomy of Radiology AI use-cases. Through this report, we intend to educate the stakeholders in healthcare and AI (AI researchers, radiologists, imaging informaticists, and regulators) about cross-disciplinary challenges and possible solutions.

Retrieval-augmented in-context learning has emerged as a powerful approach for addressing knowledge-intensive tasks using frozen language models (LM) and retrieval models (RM). Existing work has combined these in simple "retrieve-then-read" pipelines in which the RM retrieves passages that are inserted into the LM prompt. To begin to fully realize the potential of frozen LMs and RMs, we propose Demonstrate-Search-Predict (DSP), a framework that relies on passing natural language texts in sophisticated pipelines between an LM and an RM. DSP can express high-level programs that bootstrap pipeline-aware demonstrations, search for relevant passages, and generate grounded predictions, systematically breaking down problems into small transformations that the LM and RM can handle more reliably. We have written novel DSP programs for answering questions in open-domain, multi-hop, and conversational settings, establishing in early evaluations new state-of-the-art in-context learning results and delivering 37-200%, 8-40%, and 80-290% relative gains against vanilla LMs, a standard retrieve-then-read pipeline, and a contemporaneous self-ask pipeline, respectively.

State space models (SSMs) have demonstrated state-of-the-art sequence modeling performance in some modalities, but underperform attention in language modeling. Moreover, despite scaling nearly linearly in sequence length instead of quadratically, SSMs are still slower than Transformers due to poor hardware utilization. In this paper, we make progress on understanding the expressivity gap between SSMs and attention in language modeling, and on reducing the hardware barrier between SSMs and attention. First, we use synthetic language modeling tasks to understand the gap between SSMs and attention. We find that existing SSMs struggle with two capabilities: recalling earlier tokens in the sequence and comparing tokens across the sequence. To understand the impact on language modeling, we propose a new SSM layer, H3, that is explicitly designed for these abilities. H3 matches attention on the synthetic languages and comes within 0.4 PPL of Transformers on OpenWebText. Furthermore, a hybrid 125M-parameter H3-attention model that retains two attention layers surprisingly outperforms Transformers on OpenWebText by 1.0 PPL. Next, to improve the efficiency of training SSMs on modern hardware, we propose FlashConv. FlashConv uses a fused block FFT algorithm to improve efficiency on sequences up to 8K, and introduces a novel state passing algorithm that exploits the recurrent properties of SSMs to scale to longer sequences. FlashConv yields 2$\times$ speedup on the long-range arena benchmark and allows hybrid language models to generate text 1.6$\times$ faster than Transformers. Using FlashConv, we scale hybrid H3-attention language models up to 1.3B parameters on the Pile and find promising initial results, achieving lower perplexity than Transformers and outperforming Transformers in zero- and few-shot learning on a majority of tasks in the SuperGLUE benchmark.

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge typically rely on automated evaluations on limited benchmarks. There is no standard to evaluate model predictions and reasoning across a breadth of tasks. To address this, we present MultiMedQA, a benchmark combining six existing open question answering datasets spanning professional medical exams, research, and consumer queries; and HealthSearchQA, a new free-response dataset of medical questions searched online. We propose a framework for human evaluation of model answers along multiple axes including factuality, precision, possible harm, and bias. In addition, we evaluate PaLM (a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM, on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA, MMLU clinical topics), including 67.6% accuracy on MedQA (US Medical License Exam questions), surpassing prior state-of-the-art by over 17%. However, human evaluation reveals key gaps in Flan-PaLM responses. To resolve this we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, recall of knowledge, and medical reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal important limitations of today's models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLM models for clinical applications.