迄今为止，纳米级的活细胞成像仍然具有挑战性。尽管超分辨率显微镜方法使得能够在光学分辨率下方的亚细胞结构的可视化，但空间分辨率仍然足够远，对于体内生物分子的结构重建仍然足够远（即24nm厚度的微管纤维）。在这项研究中，我们提出了一种A-Net网络，并显示通过基于劣化模型的DWDC算法组合A-Net DeeD学习网络，可以显着改善由共聚焦显微镜捕获的细胞骨架图像的分辨率。利用DWDC算法构建新数据集并利用A-Net神经网络的特征（即，层数较少），我们成功地消除了噪声和絮凝结构，最初干扰了原始图像中的蜂窝结构，并改善了空间分辨率使用相对较小的数据集10次。因此，我们得出结论，将A-Net神经网络与DWDC方法结合的所提出的算法是一种合适的和普遍的方法，用于从低分辨率图像中严格的生物分子，细胞和器官的结构细节。

Dynamic Graph Neural Networks (DGNNs) have been broadly applied in various real-life applications, such as link prediction and pandemic forecast, to capture both static structural information and temporal characteristics from dynamic graphs. Combining both time-dependent and -independent components, DGNNs manifest substantial parallel computation and data reuse potentials, but suffer from severe memory access inefficiency and data transfer overhead under the canonical one-graph-at-a-time training pattern. To tackle the challenges, we propose PiPAD, a $\underline{\textbf{Pi}}pelined$ and $\underline{\textbf{PA}}rallel$ $\underline{\textbf{D}}GNN$ training framework for the end-to-end performance optimization on GPUs. From both the algorithm and runtime level, PiPAD holistically reconstructs the overall training paradigm from the data organization to computation manner. Capable of processing multiple graph snapshots in parallel, PiPAD eliminates the unnecessary data transmission and alleviates memory access inefficiency to improve the overall performance. Our evaluation across various datasets shows PiPAD achieves $1.22\times$-$9.57\times$ speedup over the state-of-the-art DGNN frameworks on three representative models.

We propose a novel teacher-student model for semi-supervised multi-organ segmentation. In teacher-student model, data augmentation is usually adopted on unlabeled data to regularize the consistent training between teacher and student. We start from a key perspective that fixed relative locations and variable sizes of different organs can provide distribution information where a multi-organ CT scan is drawn. Thus, we treat the prior anatomy as a strong tool to guide the data augmentation and reduce the mismatch between labeled and unlabeled images for semi-supervised learning. More specifically, we propose a data augmentation strategy based on partition-and-recovery N$^3$ cubes cross- and within- labeled and unlabeled images. Our strategy encourages unlabeled images to learn organ semantics in relative locations from the labeled images (cross-branch) and enhances the learning ability for small organs (within-branch). For within-branch, we further propose to refine the quality of pseudo labels by blending the learned representations from small cubes to incorporate local attributes. Our method is termed as MagicNet, since it treats the CT volume as a magic-cube and $N^3$-cube partition-and-recovery process matches with the rule of playing a magic-cube. Extensive experiments on two public CT multi-organ datasets demonstrate the effectiveness of MagicNet, and noticeably outperforms state-of-the-art semi-supervised medical image segmentation approaches, with +7% DSC improvement on MACT dataset with 10% labeled images.

The task of referring video object segmentation aims to segment the object in the frames of a given video to which the referring expressions refer. Previous methods adopt multi-stage approach and design complex pipelines to obtain promising results. Recently, the end-to-end method based on Transformer has proved its superiority. In this work, we draw on the advantages of the above methods to provide a simple and effective pipeline for RVOS. Firstly, We improve the state-of-the-art one-stage method ReferFormer to obtain mask sequences that are strongly correlated with language descriptions. Secondly, based on a reliable and high-quality keyframe, we leverage the superior performance of video object segmentation model to further enhance the quality and temporal consistency of the mask results. Our single model reaches 70.3 J &F on the Referring Youtube-VOS validation set and 63.0 on the test set. After ensemble, we achieve 64.1 on the final leaderboard, ranking 1st place on CVPR2022 Referring Youtube-VOS challenge. Code will be available at https://github.com/Zhiweihhh/cvpr2022-rvos-challenge.git.

Referring image segmentation aims to segment the target object described by a given natural language expression. Typically, referring expressions contain complex relationships between the target and its surrounding objects. The main challenge of this task is to understand the visual and linguistic content simultaneously and to find the referred object accurately among all instances in the image. Currently, the most effective way to solve the above problem is to obtain aligned multi-modal features by computing the correlation between visual and linguistic feature modalities under the supervision of the ground-truth mask. However, existing paradigms have difficulty in thoroughly understanding visual and linguistic content due to the inability to perceive information directly about surrounding objects that refer to the target. This prevents them from learning aligned multi-modal features, which leads to inaccurate segmentation. To address this issue, we present a position-aware contrastive alignment network (PCAN) to enhance the alignment of multi-modal features by guiding the interaction between vision and language through prior position information. Our PCAN consists of two modules: 1) Position Aware Module (PAM), which provides position information of all objects related to natural language descriptions, and 2) Contrastive Language Understanding Module (CLUM), which enhances multi-modal alignment by comparing the features of the referred object with those of related objects. Extensive experiments on three benchmarks demonstrate our PCAN performs favorably against the state-of-the-art methods. Our code will be made publicly available.

Continual Learning is considered a key step toward next-generation Artificial Intelligence. Among various methods, replay-based approaches that maintain and replay a small episodic memory of previous samples are one of the most successful strategies against catastrophic forgetting. However, since forgetting is inevitable given bounded memory and unbounded tasks, how to forget is a problem continual learning must address. Therefore, beyond simply avoiding catastrophic forgetting, an under-explored issue is how to reasonably forget while ensuring the merits of human memory, including 1. storage efficiency, 2. generalizability, and 3. some interpretability. To achieve these simultaneously, our paper proposes a new saliency-augmented memory completion framework for continual learning, inspired by recent discoveries in memory completion separation in cognitive neuroscience. Specifically, we innovatively propose to store the part of the image most important to the tasks in episodic memory by saliency map extraction and memory encoding. When learning new tasks, previous data from memory are inpainted by an adaptive data generation module, which is inspired by how humans complete episodic memory. The module's parameters are shared across all tasks and it can be jointly trained with a continual learning classifier as bilevel optimization. Extensive experiments on several continual learning and image classification benchmarks demonstrate the proposed method's effectiveness and efficiency.

Diffractive optical networks provide rich opportunities for visual computing tasks since the spatial information of a scene can be directly accessed by a diffractive processor without requiring any digital pre-processing steps. Here we present data class-specific transformations all-optically performed between the input and output fields-of-view (FOVs) of a diffractive network. The visual information of the objects is encoded into the amplitude (A), phase (P), or intensity (I) of the optical field at the input, which is all-optically processed by a data class-specific diffractive network. At the output, an image sensor-array directly measures the transformed patterns, all-optically encrypted using the transformation matrices pre-assigned to different data classes, i.e., a separate matrix for each data class. The original input images can be recovered by applying the correct decryption key (the inverse transformation) corresponding to the matching data class, while applying any other key will lead to loss of information. The class-specificity of these all-optical diffractive transformations creates opportunities where different keys can be distributed to different users; each user can only decode the acquired images of only one data class, serving multiple users in an all-optically encrypted manner. We numerically demonstrated all-optical class-specific transformations covering A-->A, I-->I, and P-->I transformations using various image datasets. We also experimentally validated the feasibility of this framework by fabricating a class-specific I-->I transformation diffractive network using two-photon polymerization and successfully tested it at 1550 nm wavelength. Data class-specific all-optical transformations provide a fast and energy-efficient method for image and data encryption, enhancing data security and privacy.

Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason grade is assigned based on tumor architecture on Hematoxylin and Eosin (H&E) stained whole slide images (WSI) by the pathologists. This process is time-consuming and has known interobserver variability. In the past few years, deep learning algorithms have been used to analyze histopathology images, delivering promising results for grading prostate cancer. However, most of the algorithms rely on the fully annotated datasets which are expensive to generate. In this work, we proposed a novel weakly-supervised algorithm to classify prostate cancer grades. The proposed algorithm consists of three steps: (1) extracting discriminative areas in a histopathology image by employing the Multiple Instance Learning (MIL) algorithm based on Transformers, (2) representing the image by constructing a graph using the discriminative patches, and (3) classifying the image into its Gleason grades by developing a Graph Convolutional Neural Network (GCN) based on the gated attention mechanism. We evaluated our algorithm using publicly available datasets, including TCGAPRAD, PANDA, and Gleason 2019 challenge datasets. We also cross validated the algorithm on an independent dataset. Results show that the proposed model achieved state-of-the-art performance in the Gleason grading task in terms of accuracy, F1 score, and cohen-kappa. The code is available at https://github.com/NabaviLab/Prostate-Cancer.

For guiding the UAV swarm to pass through narrow openings, a trapezoid virtual tube is designed in our previous work. In this paper, we generalize its application range to the condition that there exist obstacles inside the trapezoid virtual tube and UAVs have strict speed constraints. First, a distributed vector field controller is proposed for the trapezoid virtual tube with no obstacle inside. The relationship between the trapezoid virtual tube and the speed constraints is also presented. Then, a switching logic for the obstacle avoidance is put forward. The key point is to divide the trapezoid virtual tube containing obstacles into several sub trapezoid virtual tubes with no obstacle inside. Formal analyses and proofs are made to show that all UAVs are able to pass through the trapezoid virtual tube safely. Besides, the effectiveness of the proposed method is validated by numerical simulations and real experiments.

Unsupervised pre-training on millions of digital-born or scanned documents has shown promising advances in visual document understanding~(VDU). While various vision-language pre-training objectives are studied in existing solutions, the document textline, as an intrinsic granularity in VDU, has seldom been explored so far. A document textline usually contains words that are spatially and semantically correlated, which can be easily obtained from OCR engines. In this paper, we propose Wukong-Reader, trained with new pre-training objectives to leverage the structural knowledge nested in document textlines. We introduce textline-region contrastive learning to achieve fine-grained alignment between the visual regions and texts of document textlines. Furthermore, masked region modeling and textline-grid matching are also designed to enhance the visual and layout representations of textlines. Experiments show that our Wukong-Reader has superior performance on various VDU tasks such as information extraction. The fine-grained alignment over textlines also empowers Wukong-Reader with promising localization ability.