A new Lossy Causal Temporal Convolutional Neural Network Autoencoder for anomaly detection is proposed in this work. Our framework uses a rate-distortion loss and an entropy bottleneck to learn a compressed latent representation for the task. The main idea of using a rate-distortion loss is to introduce representation flexibility that ignores or becomes robust to unlikely events with distinctive patterns, such as anomalies. These anomalies manifest as unique distortion features that can be accurately detected in testing conditions. This new architecture allows us to train a fully unsupervised model that has high accuracy in detecting anomalies from a distortion score despite being trained with some portion of unlabelled anomalous data. This setting is in stark contrast to many of the state-of-the-art unsupervised methodologies that require the model to be only trained on "normal data". We argue that this partially violates the concept of unsupervised training for anomaly detection as the model uses an informed decision that selects what is normal from abnormal for training. Additionally, there is evidence to suggest it also effects the models ability at generalisation. We demonstrate that models that succeed in the paradigm where they are only trained on normal data fail to be robust when anomalous data is injected into the training. In contrast, our compression-based approach converges to a robust representation that tolerates some anomalous distortion. The robust representation achieved by a model using a rate-distortion loss can be used in a more realistic unsupervised anomaly detection scheme.

信息理论措施已广泛采用学习和决策问题的特征。受到这一点的启发，我们介绍了Shannon Sense的信息损失的弱形式，ii）在考虑一系列有损的连续表示（特征）时，错误（MPE）意义上的最小概率的操作损失连续观察。我们展示了几个结果揭示了这种相互作用的结果。我们的第一个结果在采用离散的损耗表示（量化）而不是原始原始观察时，在其各自的操作损失的函数中提供弱的信息损失形式的下限。从这后，我们的主要结果表明，在考虑一般的持续陈述时，特定形式的消失信息丧失（渐近信息充足的弱势概念）意味着消失的MPE损失（或渐近运营充足机会）。我们的理论调查结果支持观察到选择要捕捉信息充足性的特征表示是适当的学习，但如果预期目标在分类中实现MPE，这种选择是一种相当保守的设计原则。支持这一表明，在某些结构条件下，我们表明，可以采取信息充足的替代概念（严格弱于互信息意义上的纯粹足够的充足），以实现运动充足。

Objective: Accurate visual classification of bladder tissue during Trans-Urethral Resection of Bladder Tumor (TURBT) procedures is essential to improve early cancer diagnosis and treatment. During TURBT interventions, White Light Imaging (WLI) and Narrow Band Imaging (NBI) techniques are used for lesion detection. Each imaging technique provides diverse visual information that allows clinicians to identify and classify cancerous lesions. Computer vision methods that use both imaging techniques could improve endoscopic diagnosis. We address the challenge of tissue classification when annotations are available only in one domain, in our case WLI, and the endoscopic images correspond to an unpaired dataset, i.e. there is no exact equivalent for every image in both NBI and WLI domains. Method: We propose a semi-surprised Generative Adversarial Network (GAN)-based method composed of three main components: a teacher network trained on the labeled WLI data; a cycle-consistency GAN to perform unpaired image-to-image translation, and a multi-input student network. To ensure the quality of the synthetic images generated by the proposed GAN we perform a detailed quantitative, and qualitative analysis with the help of specialists. Conclusion: The overall average classification accuracy, precision, and recall obtained with the proposed method for tissue classification are 0.90, 0.88, and 0.89 respectively, while the same metrics obtained in the unlabeled domain (NBI) are 0.92, 0.64, and 0.94 respectively. The quality of the generated images is reliable enough to deceive specialists. Significance: This study shows the potential of using semi-supervised GAN-based classification to improve bladder tissue classification when annotations are limited in multi-domain data.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Despite the impact of psychiatric disorders on clinical health, early-stage diagnosis remains a challenge. Machine learning studies have shown that classifiers tend to be overly narrow in the diagnosis prediction task. The overlap between conditions leads to high heterogeneity among participants that is not adequately captured by classification models. To address this issue, normative approaches have surged as an alternative method. By using a generative model to learn the distribution of healthy brain data patterns, we can identify the presence of pathologies as deviations or outliers from the distribution learned by the model. In particular, deep generative models showed great results as normative models to identify neurological lesions in the brain. However, unlike most neurological lesions, psychiatric disorders present subtle changes widespread in several brain regions, making these alterations challenging to identify. In this work, we evaluate the performance of transformer-based normative models to detect subtle brain changes expressed in adolescents and young adults. We trained our model on 3D MRI scans of neurotypical individuals (N=1,765). Then, we obtained the likelihood of neurotypical controls and psychiatric patients with early-stage schizophrenia from an independent dataset (N=93) from the Human Connectome Project. Using the predicted likelihood of the scans as a proxy for a normative score, we obtained an AUROC of 0.82 when assessing the difference between controls and individuals with early-stage schizophrenia. Our approach surpassed recent normative methods based on brain age and Gaussian Process, showing the promising use of deep generative models to help in individualised analyses.

Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI models to be used clinically, they need to be made safe, reproducible and robust, and the underlying software framework must be aware of the particularities (e.g. geometry, physiology, physics) of medical data being processed. This work introduces MONAI, a freely available, community-supported, and consortium-led PyTorch-based framework for deep learning in healthcare. MONAI extends PyTorch to support medical data, with a particular focus on imaging, and provide purpose-specific AI model architectures, transformations and utilities that streamline the development and deployment of medical AI models. MONAI follows best practices for software-development, providing an easy-to-use, robust, well-documented, and well-tested software framework. MONAI preserves the simple, additive, and compositional approach of its underlying PyTorch libraries. MONAI is being used by and receiving contributions from research, clinical and industrial teams from around the world, who are pursuing applications spanning nearly every aspect of healthcare.

深度神经网络在医学图像分析中带来了显着突破。但是，由于其渴望数据的性质，医学成像项目中适度的数据集大小可能会阻碍其全部潜力。生成合成数据提供了一种有希望的替代方案，可以补充培训数据集并进行更大范围的医学图像研究。最近，扩散模型通过产生逼真的合成图像引起了计算机视觉社区的注意。在这项研究中，我们使用潜在扩散模型探索从高分辨率3D脑图像中生成合成图像。我们使用来自英国生物银行数据集的T1W MRI图像（n = 31,740）来训练我们的模型，以了解脑图像的概率分布，该脑图像以协变量为基础，例如年龄，性别和大脑结构量。我们发现我们的模型创建了现实的数据，并且可以使用条件变量有效地控制数据生成。除此之外，我们创建了一个带有100,000次脑图像的合成数据集，并使科学界公开使用。

ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

能够分析和量化人体或行为特征的系统（称为生物识别系统）正在使用和应用变异性增长。由于其从手工制作的功能和传统的机器学习转变为深度学习和自动特征提取，因此生物识别系统的性能增加到了出色的价值。尽管如此，这种快速进步的成本仍然尚不清楚。由于其不透明度，深层神经网络很难理解和分析，因此，由错误动机动机动机的隐藏能力或决定是潜在的风险。研究人员已经开始将注意力集中在理解深度神经网络及其预测的解释上。在本文中，我们根据47篇论文的研究提供了可解释生物识别技术的当前状态，并全面讨论了该领域的发展方向。

我们研究了图结构识别的问题，即在时间序列之间恢复依赖图的图。我们将这些时间序列数据建模为线性随机网络动力学系统状态的组成部分。我们假设部分可观察性，其中仅观察到一个包含网络的节点子集的状态演变。我们设计了一个从观察到的时间序列计算的新功能向量，并证明这些特征是线性可分离的，即存在一个超平面，该超平面将与连接的节点成对相关的特征群体与与断开对相关的节点相关联。这使得可以训练各种分类器进行因果推理的功能。特别是，我们使用这些功能来训练卷积神经网络（CNN）。由此产生的因果推理机制优于最先进的W.R.T.样品复杂性。受过训练的CNN概括了结构上不同的网络（密集或稀疏）和噪声级别的轮廓。值得注意的是，他们在通过合成网络（随机图的实现）训练时也很好地概括了现实世界网络。最后，提出的方法始终以成对的方式重建图，也就是说，通过确定每对相应的时间序列中的每对节点中是否存在边缘或箭头或不存在箭头。这符合大规模系统的框架，在该系统中，网络中所有节点的观察或处理都令人难以置信。