我们介绍了一种考虑复杂的环境条件，在极地地区介绍了一种在极地地区长距离海上路线计划的方法。该方法允许构建优化的路线，描述了该过程的三个主要阶段：使用不均匀网格对环境条件进行离散建模，网格最佳路径的构建以及路径平滑。为了说明不同的车辆性能，我们构建了一系列数据驱动的功能，这些功能可以应用于环境网格，以确定给定容器和网格单元的速度限制和燃料要求，以图形和地理空间表示这些数量。在描述我们的结果时，我们展示了一个示例用途，用于Polar Research船RRS David Attenborough爵士（SDA）的路线规划，核算冰的性能特征，并验证韦德尔海地区的时空路线构建，南极洲。我们通过证明路线的变化取决于季节性海冰可变性，所使用的路线规划目标函数的差异以及其他环境条件（如电流）的存在来证明这种路线构建方法的多功能性。为了证明我们的方法的普遍性，我们在北极海洋和波罗的海中介绍了例子。本手稿中概述的技术是通用的，因此可以应用于具有不同特征的血管。我们的方法不仅可以拥有一个船只计划程序，而且我们概述了该工作流程如何适用于更广泛的社区，例如商业和乘客运输。

Recent advances in upper limb prostheses have led to significant improvements in the number of movements provided by the robotic limb. However, the method for controlling multiple degrees of freedom via user-generated signals remains challenging. To address this issue, various machine learning controllers have been developed to better predict movement intent. As these controllers become more intelligent and take on more autonomy in the system, the traditional approach of representing the human-machine interface as a human controlling a tool becomes limiting. One possible approach to improve the understanding of these interfaces is to model them as collaborative, multi-agent systems through the lens of joint action. The field of joint action has been commonly applied to two human partners who are trying to work jointly together to achieve a task, such as singing or moving a table together, by effecting coordinated change in their shared environment. In this work, we compare different prosthesis controllers (proportional electromyography with sequential switching, pattern recognition, and adaptive switching) in terms of how they present the hallmarks of joint action. The results of the comparison lead to a new perspective for understanding how existing myoelectric systems relate to each other, along with recommendations for how to improve these systems by increasing the collaborative communication between each partner.

SchNetPack is a versatile neural networks toolbox that addresses both the requirements of method development and application of atomistic machine learning. Version 2.0 comes with an improved data pipeline, modules for equivariant neural networks as well as a PyTorch implementation of molecular dynamics. An optional integration with PyTorch Lightning and the Hydra configuration framework powers a flexible command-line interface. This makes SchNetPack 2.0 easily extendable with custom code and ready for complex training task such as generation of 3d molecular structures.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Although prediction models for delirium, a commonly occurring condition during general hospitalization or post-surgery, have not gained huge popularity, their algorithmic bias evaluation is crucial due to the existing association between social determinants of health and delirium risk. In this context, using MIMIC-III and another academic hospital dataset, we present some initial experimental evidence showing how sociodemographic features such as sex and race can impact the model performance across subgroups. With this work, our intent is to initiate a discussion about the intersectionality effects of old age, race and socioeconomic factors on the early-stage detection and prevention of delirium using ML.

Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI models to be used clinically, they need to be made safe, reproducible and robust, and the underlying software framework must be aware of the particularities (e.g. geometry, physiology, physics) of medical data being processed. This work introduces MONAI, a freely available, community-supported, and consortium-led PyTorch-based framework for deep learning in healthcare. MONAI extends PyTorch to support medical data, with a particular focus on imaging, and provide purpose-specific AI model architectures, transformations and utilities that streamline the development and deployment of medical AI models. MONAI follows best practices for software-development, providing an easy-to-use, robust, well-documented, and well-tested software framework. MONAI preserves the simple, additive, and compositional approach of its underlying PyTorch libraries. MONAI is being used by and receiving contributions from research, clinical and industrial teams from around the world, who are pursuing applications spanning nearly every aspect of healthcare.

2型糖尿病（T2DM）的早期诊断对于及时的治疗干预措施和生活方式改变至关重要。随着医学成像数据在许多患者群体中变得更广泛可用，我们试图研究是否可以在表格学习分类器模型中利用图像衍生的表型数据来预测T2DM的发病率，而无需使用侵入性血液实验室测量。我们表明，使用图像衍生表型的神经网络和决策树模型都可以预测患者T2DM状态的召回评分高达87.6％。我们还提出了与“ Syntha1c编码器”相同的结构的新颖使用，这些结构能够输出模仿血液血红蛋白A1C经验实验室测量值的可解释值。最后，我们证明了T2DM风险预测模型对输入矢量成分中小扰动的敏感性可用于预测从以前看不见的患者人群中取样的协变量的性能。

加速的MRI从稀疏采样的信号数据中重建了临床解剖学的图像，以减少患者扫描时间。尽管最近的作品利用了深入的学习来完成这项任务，但这种方法通常只在没有信号损坏或资源限制的模拟环境中进行了探索。在这项工作中，我们探索了神经网络MRI图像重建器的增强，以增强其临床相关性。也就是说，我们提出了一个用于检测图像源的Convnet模型，该模型可以实现分类器$ f_2 $得分为$ 79.1 \％$ $。我们还证明，具有可变加速度因子的MR信号数据的培训重建器可以在临床患者扫描期间提高其平均性能，最高$ 2 \％$。当模型学会重建多个解剖和方向的MR图像时，我们提供损失功能来克服灾难性的遗忘。最后，我们提出了一种使用模拟幻影数据在临床获取数据集和计算功能有限的情况下使用模拟幻影数据预先培训重建器的方法。我们的结果为加速MRI的临床适应提供了潜在的途径。

本文提出了一种延时3D细胞分析的方法。具体而言，我们考虑了准确定位和定量分析亚细胞特征的问题，以及从延时3D共聚焦细胞图像堆栈跟踪单个细胞的问题。细胞的异质性和多维图像的体积提出了对细胞形态发生和发育的完全自动化分析的主要挑战。本文是由路面细胞生长过程和构建定量形态发生模型的动机。我们提出了一种基于深度特征的分割方法，以准确检测和标记每个细胞区域。基于邻接图的方法用于提取分段细胞的亚细胞特征。最后，提出了使用多个单元格特征的基于强大的图形跟踪算法在不同的时间实例中关联单元格。提供了广泛的实验结果，并证明了所提出的方法的鲁棒性。该代码可在GitHub上获得，该方法可通过Bisque Portal作为服务可用。

多实施学习（MIL）被广泛用于对病理整体幻灯片图像（WSIS）的计算机辅助解释，以解决缺乏像素或贴片的注释。通常，这种方法直接应用“自然图像驱动”的MIL算法，该算法忽略了WSIS的多尺度（即金字塔）性质。现成的MIL算法通常部署在单个WSIS（例如20x放大倍率）上，而人类病理学家通常以多尺度的方式汇总全球和局部模式（例如，通过放大不同大型）。在这项研究中，我们提出了一种新型的跨尺度注意机制，以明确地将尺度间相互作用汇总到单个MIL网络的克罗恩病（CD）（CD），这是炎症性肠病的一种形式。本文的贡献是两个方面：（1）提出了一种跨尺度注意机制，以从不同分辨率的多尺度相互作用汇总特征； （2）生成差异多尺度注意的可视化，以定位可解释的病变模式。通过训练来自20名CD患者的约250,000 H＆E染色的上升结肠（AC）斑块，在不同尺度上训练30个健康对照样品，我们的方法在曲线下（AUC）得分为0.8924，与基线模型相比达到0.8924。官方实施可在https://github.com/hrlblab/cs-mil上公开获得。