尽管近期因因果推断领域的进展，迄今为止没有关于从观察数据的收集治疗效应估算的方法。对临床实践的结果是，当缺乏随机试验的结果时，没有指导在真实情景中似乎有效的指导。本文提出了一种务实的方法，以获得从观察性研究的治疗效果的初步但稳健地估算，为前线临床医生提供对其治疗策略的信心程度。我们的研究设计适用于一个公开问题，估算Covid-19密集护理患者的拳击机动的治疗效果。

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Objective: Social Determinants of Health (SDOH) influence personal health outcomes and health systems interactions. Health systems capture SDOH information through structured data and unstructured clinical notes; however, clinical notes often contain a more comprehensive representation of several key SDOH. The objective of this work is to assess the SDOH information gain achievable by extracting structured semantic representations of SDOH from the clinical narrative and combining these extracted representations with available structured data. Materials and Methods: We developed a natural language processing (NLP) information extraction model for SDOH that utilizes a deep learning entity and relation extraction architecture. In an electronic health record (EHR) case study, we applied the SDOH extractor to a large existing clinical data set with over 200,000 patients and 400,000 notes and compared the extracted information with available structured data. Results: The SDOH extractor achieved 0.86 F1 on a withheld test set. In the EHR case study, we found 19\% of current tobacco users, 10\% of drug users, and 32\% of homeless patients only include documentation of these risk factors in the clinical narrative. Conclusions: Patients who are at-risk for negative health outcomes due to SDOH may be better served if health systems are able to identify SDOH risk factors and associated social needs. Structured semantic representations of text-encoded SDOH information can augment existing structured, and this more comprehensive SDOH representation can assist health systems in identifying and addressing social needs.

This paper is a technical overview of DeepMind and Google's recent work on reinforcement learning for controlling commercial cooling systems. Building on expertise that began with cooling Google's data centers more efficiently, we recently conducted live experiments on two real-world facilities in partnership with Trane Technologies, a building management system provider. These live experiments had a variety of challenges in areas such as evaluation, learning from offline data, and constraint satisfaction. Our paper describes these challenges in the hope that awareness of them will benefit future applied RL work. We also describe the way we adapted our RL system to deal with these challenges, resulting in energy savings of approximately 9% and 13% respectively at the two live experiment sites.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Quantum-enhanced data science, also known as quantum machine learning (QML), is of growing interest as an application of near-term quantum computers. Variational QML algorithms have the potential to solve practical problems on real hardware, particularly when involving quantum data. However, training these algorithms can be challenging and calls for tailored optimization procedures. Specifically, QML applications can require a large shot-count overhead due to the large datasets involved. In this work, we advocate for simultaneous random sampling over both the dataset as well as the measurement operators that define the loss function. We consider a highly general loss function that encompasses many QML applications, and we show how to construct an unbiased estimator of its gradient. This allows us to propose a shot-frugal gradient descent optimizer called Refoqus (REsource Frugal Optimizer for QUantum Stochastic gradient descent). Our numerics indicate that Refoqus can save several orders of magnitude in shot cost, even relative to optimizers that sample over measurement operators alone.

运行时验证（RV）有可能使安全关键系统的安全操作太复杂而无法正式验证，例如机器人操作系统2（ROS2）应用程序。编写正确的监视器本身可能很复杂，监视子系统中的错误威胁着整个任务。本文概述了一种正式的方法，该方法是根据用结构化的自然语言编写的要求为自动驾驶机器人生成运行时监视器的。我们的方法通过OGMA集成工具将正式需求启发工具（FRET）与Copilot（运行时验证框架）集成在一起。 FRET用于用明确的语义指定需求，然后将其自动转化为时间逻辑公式。 OGMA从FRET输出中生成监视规格，该规范已编译为硬实时C99。为了促进ROS2中的显示器的集成，我们已经扩展了OGMA，以生成定义监视节点的ROS2软件包，该节点在新数据可用时运行监视器，并发布任何违规结果。我们方法的目的是将生成的ROS2软件包视为黑匣子，并以最小的努力将它们集成到更大的ROS2系统中。

通用数据模型解决了标准化电子健康记录（EHR）数据的许多挑战，但无法将其集成深度表型所需的资源。开放的生物学和生物医学本体论（OBO）铸造本体论提供了可用于生物学知识的语义计算表示，并能够整合多种生物医学数据。但是，将EHR数据映射到OBO Foundry本体论需要大量的手动策展和域专业知识。我们介绍了一个框架，用于将观察性医学成果合作伙伴关系（OMOP）标准词汇介绍给OBO铸造本体。使用此框架，我们制作了92,367条条件，8,615种药物成分和10,673个测量结果的映射。域专家验证了映射准确性，并且在24家医院进行检查时，映射覆盖了99％的条件和药物成分和68％的测量结果。最后，我们证明OMOP2OBO映射可以帮助系统地识别可能受益于基因检测的未诊断罕见病患者。

我们研究了量子多体系统的哈密顿量的参数的问题，鉴于对系统的访问有限。在这项工作中，我们基于最近通过衍生估计进行哈密顿学习的方法。我们提出了一项协议，以改善先前作品的缩放依赖性，尤其是在与哈密顿式结构有关的参数方面（例如，其locality $ k $）。此外，通过在我们的协议的性能上得出精确的界限，我们能够在我们的学习协议中为高参数的理论上最佳设置提供精确的数值处方，例如最大进化时间（当统一动力学学习时）或最低温度（当与吉布斯国家学习时）。多亏了这些改进，我们的协议对于大型问题很实际：我们通过对80克系统的协议进行数值模拟来证明这一点。

在标准量子传感（QS）任务中，One旨在通过系统测量结果估算未知参数$ \ theta $，该参数$ \ theta $编码为$ n $ qubit的探测态。此任务的成功取决于将参数的变化与系统响应$ \ MATHCAL {r}（\ theta）$（即测量结果的变化）相关联的能力。对于简单的情况，$ \ Mathcal {r}（\ theta）$的形式是已知的，但是对于现实情况而言，不能说相同，因为不存在一般的封闭式表达式。在这项工作中，我们为QS提供了基于推理的方案。我们表明，对于一般的编码统一家庭，$ \ Mathcal {r}（\ theta）$只能通过仅在$ 2N+1 $参数下测量系统响应来充分表征。反过来，这使我们能够在测量响应中推断未知参数的值，并确定感应方案的灵敏度，这表征了其整体性能。我们表明，如果一个人以许多镜头来测量系统响应，则推理错误的可能性很小，但仅缩放为$ \ omega（\ log^3（n）/\ delta^2） $。此外，所提供的框架可以广泛应用，因为它对于任意探针状态和测量方案仍然有效，甚至在存在量子噪声的情况下也保持。我们还讨论了如何将结果扩展到统一家庭之外。最后，为了展示我们的方法，我们在实际量子硬件和数值模拟中实现了它的QS任务。