在术前设置中，使用了数字重建的X光片（DRR）来解决诸如切片到体积注册和3D重建之类的反问题。在术中成像中，DRR的实用性受到实时生成它们的挑战的限制，并支持依赖重复的DRR合成的优化程序。尽管通过算法改进和GPU实现加速了DRR的生成，但基于DRR的优化仍然很慢，因为大多数DRR发电机没有提供有关成像参数的梯度的直接方法。为了使DRR与基于梯度的优化和深度学习框架互操作，我们重新重新制定了Siddon的方法，Siddon的方法是DRR生成中使用的最流行的射线追踪算法，作为一系列矢量化的张量操作。我们在Pytorch中实现了Siddon方法的矢量化版本，利用了图书馆的强大自动分化引擎，使该DRR发电机相对于其参数完全可区分。此外，使用GPU加速张量计算使我们的矢量实现能够实现与CUDA和C ++实现的最新DRR发电机相同的渲染速度。我们在切片到体积注册的上下文中说明了所得的方法。此外，我们的模拟表明，在最佳解决方案附近，切片到体积注册问题的损失景观是凸的，基于梯度的注册有望比普遍的无梯度优化策略更快。提出的DRR发电机使快速的计算机视觉算法能够在微创过程中支持图像指导。我们的实施公开可在https://github.com/v715/diffdrr上获得。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge typically rely on automated evaluations on limited benchmarks. There is no standard to evaluate model predictions and reasoning across a breadth of tasks. To address this, we present MultiMedQA, a benchmark combining six existing open question answering datasets spanning professional medical exams, research, and consumer queries; and HealthSearchQA, a new free-response dataset of medical questions searched online. We propose a framework for human evaluation of model answers along multiple axes including factuality, precision, possible harm, and bias. In addition, we evaluate PaLM (a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM, on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA, MMLU clinical topics), including 67.6% accuracy on MedQA (US Medical License Exam questions), surpassing prior state-of-the-art by over 17%. However, human evaluation reveals key gaps in Flan-PaLM responses. To resolve this we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, recall of knowledge, and medical reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal important limitations of today's models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLM models for clinical applications.

We propose a fairness-aware learning framework that mitigates intersectional subgroup bias associated with protected attributes. Prior research has primarily focused on mitigating one kind of bias by incorporating complex fairness-driven constraints into optimization objectives or designing additional layers that focus on specific protected attributes. We introduce a simple and generic bias mitigation approach that prevents models from learning relationships between protected attributes and output variable by reducing mutual information between them. We demonstrate that our approach is effective in reducing bias with little or no drop in accuracy. We also show that the models trained with our learning framework become causally fair and insensitive to the values of protected attributes. Finally, we validate our approach by studying feature interactions between protected and non-protected attributes. We demonstrate that these interactions are significantly reduced when applying our bias mitigation.

Detecting actions in untrimmed videos should not be limited to a small, closed set of classes. We present a simple, yet effective strategy for open-vocabulary temporal action detection utilizing pretrained image-text co-embeddings. Despite being trained on static images rather than videos, we show that image-text co-embeddings enable openvocabulary performance competitive with fully-supervised models. We show that the performance can be further improved by ensembling the image-text features with features encoding local motion, like optical flow based features, or other modalities, like audio. In addition, we propose a more reasonable open-vocabulary evaluation setting for the ActivityNet data set, where the category splits are based on similarity rather than random assignment.

Context is vital for commonsense moral reasoning. "Lying to a friend" is wrong if it is meant to deceive them, but may be morally okay if it is intended to protect them. Such nuanced but salient contextual information can potentially flip the moral judgment of an action. Thus, we present ClarifyDelphi, an interactive system that elicits missing contexts of a moral situation by generating clarification questions such as "Why did you lie to your friend?". Our approach is inspired by the observation that questions whose potential answers lead to diverging moral judgments are the most informative. We learn to generate questions using Reinforcement Learning, by maximizing the divergence between moral judgements of hypothetical answers to a question. Human evaluation shows that our system generates more relevant, informative and defeasible questions compared to other question generation baselines. ClarifyDelphi assists informed moral reasoning processes by seeking additional morally consequential context to disambiguate social and moral situations.

Crop type maps are critical for tracking agricultural land use and estimating crop production. Remote sensing has proven an efficient and reliable tool for creating these maps in regions with abundant ground labels for model training, yet these labels remain difficult to obtain in many regions and years. NASA's Global Ecosystem Dynamics Investigation (GEDI) spaceborne lidar instrument, originally designed for forest monitoring, has shown promise for distinguishing tall and short crops. In the current study, we leverage GEDI to develop wall-to-wall maps of short vs tall crops on a global scale at 10 m resolution for 2019-2021. Specifically, we show that (1) GEDI returns can reliably be classified into tall and short crops after removing shots with extreme view angles or topographic slope, (2) the frequency of tall crops over time can be used to identify months when tall crops are at their peak height, and (3) GEDI shots in these months can then be used to train random forest models that use Sentinel-2 time series to accurately predict short vs. tall crops. Independent reference data from around the world are then used to evaluate these GEDI-S2 maps. We find that GEDI-S2 performed nearly as well as models trained on thousands of local reference training points, with accuracies of at least 87% and often above 90% throughout the Americas, Europe, and East Asia. Systematic underestimation of tall crop area was observed in regions where crops frequently exhibit low biomass, namely Africa and South Asia, and further work is needed in these systems. Although the GEDI-S2 approach only differentiates tall from short crops, in many landscapes this distinction goes a long way toward mapping the main individual crop types. The combination of GEDI and Sentinel-2 thus presents a very promising path towards global crop mapping with minimal reliance on ground data.

Language models have been shown to perform better with an increase in scale on a wide variety of tasks via the in-context learning paradigm. In this paper, we investigate the hypothesis that the ability of a large language model to in-context learn-perform a task is not uniformly spread across all of its underlying components. Using a 66 billion parameter language model (OPT-66B) across a diverse set of 14 downstream tasks, we find this is indeed the case: $\sim$70% of attention heads and $\sim$20% of feed forward networks can be removed with minimal decline in task performance. We find substantial overlap in the set of attention heads (un)important for in-context learning across tasks and number of in-context examples. We also address our hypothesis through a task-agnostic lens, finding that a small set of attention heads in OPT-66B score highly on their ability to perform primitive induction operations associated with in-context learning, namely, prefix matching and copying. These induction heads overlap with task-specific important heads, suggesting that induction heads are among the heads capable of more sophisticated behaviors associated with in-context learning. Overall, our study provides several insights that indicate large language models may be under-trained to perform in-context learning and opens up questions on how to pre-train language models to more effectively perform in-context learning.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Of late, insurance fraud detection has assumed immense significance owing to the huge financial & reputational losses fraud entails and the phenomenal success of the fraud detection techniques. Insurance is majorly divided into two categories: (i) Life and (ii) Non-life. Non-life insurance in turn includes health insurance and auto insurance among other things. In either of the categories, the fraud detection techniques should be designed in such a way that they capture as many fraudulent transactions as possible. Owing to the rarity of fraudulent transactions, in this paper, we propose a chaotic variational autoencoder (C-VAE to perform one-class classification (OCC) on genuine transactions. Here, we employed the logistic chaotic map to generate random noise in the latent space. The effectiveness of C-VAE is demonstrated on the health insurance fraud and auto insurance datasets. We considered vanilla Variational Auto Encoder (VAE) as the baseline. It is observed that C-VAE outperformed VAE in both datasets. C-VAE achieved a classification rate of 77.9% and 87.25% in health and automobile insurance datasets respectively. Further, the t-test conducted at 1% level of significance and 18 degrees of freedom infers that C-VAE is statistically significant than the VAE.