To facilitate research on text generation, this paper presents a comprehensive and unified library, TextBox 2.0, focusing on the use of pre-trained language models (PLMs). To be comprehensive, our library covers $13$ common text generation tasks and their corresponding $83$ datasets and further incorporates $45$ PLMs covering general, translation, Chinese, dialogue, controllable, distilled, prompting, and lightweight PLMs. We also implement $4$ efficient training strategies and provide $4$ generation objectives for pre-training new PLMs from scratch. To be unified, we design the interfaces to support the entire research pipeline (from data loading to training and evaluation), ensuring that each step can be fulfilled in a unified way. Despite the rich functionality, it is easy to use our library, either through the friendly Python API or command line. To validate the effectiveness of our library, we conduct extensive experiments and exemplify four types of research scenarios. The project is released at the link: https://github.com/RUCAIBox/TextBox.

This technical report briefly describes our JDExplore d-team's Vega v2 submission on the SuperGLUE leaderboard. SuperGLUE is more challenging than the widely used general language understanding evaluation (GLUE) benchmark, containing eight difficult language understanding tasks, including question answering, natural language inference, word sense disambiguation, coreference resolution, and reasoning. [Method] Instead of arbitrarily increasing the size of a pretrained language model (PLM), our aim is to 1) fully extract knowledge from the input pretraining data given a certain parameter budget, e.g., 6B, and 2) effectively transfer this knowledge to downstream tasks. To achieve goal 1), we propose self-evolution learning for PLMs to wisely predict the informative tokens that should be masked, and supervise the masked language modeling (MLM) process with rectified smooth labels. For goal 2), we leverage the prompt transfer technique to improve the low-resource tasks by transferring the knowledge from the foundation model and related downstream tasks to the target task. [Results] According to our submission record (Oct. 2022), with our optimized pretraining and fine-tuning strategies, our 6B Vega method achieved new state-of-the-art performance on 4/8 tasks, sitting atop the SuperGLUE leaderboard on Oct. 8, 2022, with an average score of 91.3.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Improving model's generalizability against domain shifts is crucial, especially for safety-critical applications such as autonomous driving. Real-world domain styles can vary substantially due to environment changes and sensor noises, but deep models only know the training domain style. Such domain style gap impedes model generalization on diverse real-world domains. Our proposed Normalization Perturbation (NP) can effectively overcome this domain style overfitting problem. We observe that this problem is mainly caused by the biased distribution of low-level features learned in shallow CNN layers. Thus, we propose to perturb the channel statistics of source domain features to synthesize various latent styles, so that the trained deep model can perceive diverse potential domains and generalizes well even without observations of target domain data in training. We further explore the style-sensitive channels for effective style synthesis. Normalization Perturbation only relies on a single source domain and is surprisingly effective and extremely easy to implement. Extensive experiments verify the effectiveness of our method for generalizing models under real-world domain shifts.

Persona-based dialogue systems aim to generate consistent responses based on historical context and predefined persona. Unlike conventional dialogue generation, the persona-based dialogue needs to consider both dialogue context and persona, posing a challenge for coherent training. Specifically, this requires a delicate weight balance between context and persona. To achieve that, in this paper, we propose an effective framework with Persona-Adaptive Attention (PAA), which adaptively integrates the weights from the persona and context information via our designed attention. In addition, a dynamic masking mechanism is applied to the PAA to not only drop redundant information in context and persona but also serve as a regularization mechanism to avoid overfitting. Experimental results demonstrate the superiority of the proposed PAA framework compared to the strong baselines in both automatic and human evaluation. Moreover, the proposed PAA approach can perform equivalently well in a low-resource regime compared to models trained in a full-data setting, which achieve a similar result with only 20% to 30% of data compared to the larger models trained in the full-data setting. To fully exploit the effectiveness of our design, we designed several variants for handling the weighted information in different ways, showing the necessity and sufficiency of our weighting and masking designs.

Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high-dimensional, sparse, heterogeneous, and have complicated dependency structures, making analyses using conventional machine learning approaches challenging and impractical. In tackling these challenges, deep learning often demonstrates superior performance compared to traditional machine learning methods. In this work, we give a comprehensive survey on deep learning in single-cell analysis. We first introduce background on single-cell technologies and their development, as well as fundamental concepts of deep learning including the most popular deep architectures. We present an overview of the single-cell analytic pipeline pursued in research applications while noting divergences due to data sources or specific applications. We then review seven popular tasks spanning through different stages of the single-cell analysis pipeline, including multimodal integration, imputation, clustering, spatial domain identification, cell-type deconvolution, cell segmentation, and cell-type annotation. Under each task, we describe the most recent developments in classical and deep learning methods and discuss their advantages and disadvantages. Deep learning tools and benchmark datasets are also summarized for each task. Finally, we discuss the future directions and the most recent challenges. This survey will serve as a reference for biologists and computer scientists, encouraging collaborations.

Named entity recognition is a traditional task in natural language processing. In particular, nested entity recognition receives extensive attention for the widespread existence of the nesting scenario. The latest research migrates the well-established paradigm of set prediction in object detection to cope with entity nesting. However, the manual creation of query vectors, which fail to adapt to the rich semantic information in the context, limits these approaches. An end-to-end entity detection approach with proposer and regressor is presented in this paper to tackle the issues. First, the proposer utilizes the feature pyramid network to generate high-quality entity proposals. Then, the regressor refines the proposals for generating the final prediction. The model adopts encoder-only architecture and thus obtains the advantages of the richness of query semantics, high precision of entity localization, and easiness of model training. Moreover, we introduce the novel spatially modulated attention and progressive refinement for further improvement. Extensive experiments demonstrate that our model achieves advanced performance in flat and nested NER, achieving a new state-of-the-art F1 score of 80.74 on the GENIA dataset and 72.38 on the WeiboNER dataset.

Although Deep Neural Networks (DNNs) have achieved impressive results in computer vision, their exposed vulnerability to adversarial attacks remains a serious concern. A series of works has shown that by adding elaborate perturbations to images, DNNs could have catastrophic degradation in performance metrics. And this phenomenon does not only exist in the digital space but also in the physical space. Therefore, estimating the security of these DNNs-based systems is critical for safely deploying them in the real world, especially for security-critical applications, e.g., autonomous cars, video surveillance, and medical diagnosis. In this paper, we focus on physical adversarial attacks and provide a comprehensive survey of over 150 existing papers. We first clarify the concept of the physical adversarial attack and analyze its characteristics. Then, we define the adversarial medium, essential to perform attacks in the physical world. Next, we present the physical adversarial attack methods in task order: classification, detection, and re-identification, and introduce their performance in solving the trilemma: effectiveness, stealthiness, and robustness. In the end, we discuss the current challenges and potential future directions.

2D低剂量单板腹部计算机断层扫描（CT）切片可直接测量身体成分，这对于对衰老的健康关系进行定量表征至关重要。然而，由于不同年内获得的纵向切片之间的位置方差，使用2D腹部切片对人体成分变化的纵向分析具有挑战性。为了减少位置差异，我们将条件生成模型扩展到我们的C-斜肌，该模型在腹部区域进行任意轴向切片作为条件，并通过估计潜在空间的结构变化来生成定义的椎骨水平切片。对来自内部数据集的1170名受试者的实验和BTCV Miccai挑战赛的50名受试者的实验表明，我们的模型可以从现实主义和相似性方面产生高质量的图像。来自巴尔的摩纵向研究（BLSA）数据集的20名受试者的外部实验，其中包含纵向单腹部切片验证了我们的方法可以在肌肉和内脏脂肪面积方面与切片的位置方差进行协调。我们的方法提供了一个有希望的方向，将切片从不同的椎骨水平映射到目标切片，以减少单个切片纵向分析的位置差异。源代码可在以下网址获得：https：//github.com/masilab/c-slicegen。

Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis. Transformer reformats the image into separate patches and realize global communication via the self-attention mechanism. However, positional information between patches is hard to preserve in such 1D sequences, and loss of it can lead to sub-optimal performance when dealing with large amounts of heterogeneous tissues of various sizes in 3D medical image segmentation. Additionally, current methods are not robust and efficient for heavy-duty medical segmentation tasks such as predicting a large number of tissue classes or modeling globally inter-connected tissues structures. Inspired by the nested hierarchical structures in vision transformer, we proposed a novel 3D medical image segmentation method (UNesT), employing a simplified and faster-converging transformer encoder design that achieves local communication among spatially adjacent patch sequences by aggregating them hierarchically. We extensively validate our method on multiple challenging datasets, consisting anatomies of 133 structures in brain, 14 organs in abdomen, 4 hierarchical components in kidney, and inter-connected kidney tumors). We show that UNesT consistently achieves state-of-the-art performance and evaluate its generalizability and data efficiency. Particularly, the model achieves whole brain segmentation task complete ROI with 133 tissue classes in single network, outperforms prior state-of-the-art method SLANT27 ensembled with 27 network tiles, our model performance increases the mean DSC score of the publicly available Colin and CANDI dataset from 0.7264 to 0.7444 and from 0.6968 to 0.7025, respectively.