Force modulation of robotic manipulators has been extensively studied for several decades. However, it is not yet commonly used in safety-critical applications due to a lack of accurate interaction contact modeling and weak performance guarantees - a large proportion of them concerning the modulation of interaction forces. This study presents a high-level framework for simultaneous trajectory optimization and force control of the interaction between a manipulator and soft environments, which is prone to external disturbances. Sliding friction and normal contact force are taken into account. The dynamics of the soft contact model and the manipulator are simultaneously incorporated in a trajectory optimizer to generate desired motion and force profiles. A constrained optimization framework based on Alternative Direction Method of Multipliers (ADMM) has been employed to efficiently generate real-time optimal control inputs and high-dimensional state trajectories in a Model Predictive Control fashion. Experimental validation of the model performance is conducted on a soft substrate with known material properties using a Cartesian space force control mode. Results show a comparison of ground truth and real-time model-based contact force and motion tracking for multiple Cartesian motions in the valid range of the friction model. It is shown that a contact model-based motion planner can compensate for frictional forces and motion disturbances and improve the overall motion and force tracking accuracy. The proposed high-level planner has the potential to facilitate the automation of medical tasks involving the manipulation of compliant, delicate, and deformable tissues.

在这封信中，我们提出了一种多功能的层次离线计划算法，以及用于敏捷四足球运动的在线控制管道。我们的离线规划师在优化降低阶模型和全身轨迹优化的质心动力学之间进行交替，以实现动力学共识。我们使用等椭圆形参数化的新型动量惰性质地优化能够通过``惯性塑造''来产生高度的杂技运动。我们的全身优化方法可显着改善基于标准DDP的方法的质量从质心层中利用反馈。对于在线控制，我们通过完整的质心动力学的线性转换开发了一种新颖的凸模型预测控制方案。我们的控制器可以在单个优化中有效地对接触力和关节加速度有效地优化，从而实现更直接的加速度，从而实现更直接的优化与现有四倍体MPC控制器相比，跟踪动量丰富的动作。我们在四个不同的动态操作中证明了我们的轨迹计划者的能力和通用性。然后，我们在MIT MINI Cheetah平台上展示了​​一个硬件实验，以证明整个计划的性能和整个计划的性能和性能扭曲的控制管道跳动。

耐药性是对全球健康的重大威胁，以及整个疾病和药物发育的临床治疗中的重要疑虑。与药物结合有关的蛋白质中的突变是适应性耐药性的常见原因。因此，对突变如何影响药物和靶蛋白之间的相互作用的定量估计对于药物开发和临床实践来说是至关重要的。已经证明，依赖于分子动力学模拟，Rosetta方案以及机器学习方法的计算方法能够预测对蛋白质突变的配体亲和力变化。然而，严重限制的样本量和重质噪声诱导的过烧和泛化问题已经很广泛地采用了用于研究耐药性的机器学习。在本文中，我们提出了一种稳健的机器学习方法，称为Spldextratees，其可以准确地预测蛋白质突变并鉴定引起抗性突变的配体结合亲和力。特别是，所提出的方法按照易于学习的样本开始的特定方案级别，逐渐融入训练中的特定方案，然后在训练中迭代，然后在样本权重再验计算和模型更新之间迭代。此外，我们计算了基于物理的基于物理的结构特征，为机器学习模型提供了对这种数据有限预测任务的蛋白质的有价值的域知识。该实验证实了提出的方法在三种情况下预测激酶抑制剂抗性的方法，并实现了与分子动力学和Rosetta方法相当的预测准确性，具有较少的计算成本。

本文迈出了一个全局线性时间逻辑规范的反应性，分层多机器人任务分配和计划框架的第一步。四倍体机器人和轮式机器人的功能都可以通过一个异质团队来完成各种导航和交付任务。但是，当部署在现实世界中时，所有机器人都可能容易受到不同类型的干扰，包括但不限于运动失败，人类干预和环境的障碍。为了解决这些干扰，我们建议任务级的本地和全局重新分配策略，以有效地在线生成更新的动作状态序列，同时保证完成原始任务的完成。这些任务重新分配方法消除了重建整个计划或重新合成新任务的方法。为了将任务计划者与低级输入集成，行为树执行层监视不同类型的干扰，并采用重新分配方法来制定相应的恢复策略。为了评估该计划框架，在现实的医院环境中进行了动态模拟，其异质机器人团队由四足动物和轮式机器人组成，用于交付任务。

阅读理解是一个复杂的认知过程，涉及许多人类大脑活动。大量作品研究了在信息检索相关方案中阅读理解的模式和注意力分配。但是，关于阅读理解过程中人脑中发生的事情以及这些认知活动如何影响信息检索过程，知之甚少。此外，随着脑成像技术（例如脑电图（EEG））的进步，几乎可以实时收集大脑信号，并探索是否可以用作反馈来促进信息获取性能。在本文中，我们仔细设计了一项基于实验室的用户研究，以调查阅读理解过程中的大脑活动。我们的发现表明，神经反应随着不同类型的阅读内容而变化，即可以满足用户信息需求和无法无法满足的内容的内容。我们建议在阅读理解过程中以微观时间量表以微观时间量表来支持各种认知活动，例如认知负载，语义主题理解和推论处理。从这些发现中，我们说明了一些有关信息检索任务的见解，例如排名模型构建和界面设计。此外，我们建议有可能检测主动现实世界系统的阅读理解状态。为此，我们为基于脑电图的阅读理解建模（UERCM）提出了一个统一的框架。为了验证其有效性，我们基于脑电图特征进行了大量的实验，以进行两项阅读理解任务：回答句子分类和回答提取。结果表明，通过大脑信号提高两个任务的性能是可行的。

Accurate determination of a small molecule candidate (ligand) binding pose in its target protein pocket is important for computer-aided drug discovery. Typical rigid-body docking methods ignore the pocket flexibility of protein, while the more accurate pose generation using molecular dynamics is hindered by slow protein dynamics. We develop a tiered tensor transform (3T) algorithm to rapidly generate diverse protein-ligand complex conformations for both pose and affinity estimation in drug screening, requiring neither machine learning training nor lengthy dynamics computation, while maintaining both coarse-grain-like coordinated protein dynamics and atomistic-level details of the complex pocket. The 3T conformation structures we generate are closer to experimental co-crystal structures than those generated by docking software, and more importantly achieve significantly higher accuracy in active ligand classification than traditional ensemble docking using hundreds of experimental protein conformations. 3T structure transformation is decoupled from the system physics, making future usage in other computational scientific domains possible.

For Prognostics and Health Management (PHM) of Lithium-ion (Li-ion) batteries, many models have been established to characterize their degradation process. The existing empirical or physical models can reveal important information regarding the degradation dynamics. However, there is no general and flexible methods to fuse the information represented by those models. Physics-Informed Neural Network (PINN) is an efficient tool to fuse empirical or physical dynamic models with data-driven models. To take full advantage of various information sources, we propose a model fusion scheme based on PINN. It is implemented by developing a semi-empirical semi-physical Partial Differential Equation (PDE) to model the degradation dynamics of Li-ion-batteries. When there is little prior knowledge about the dynamics, we leverage the data-driven Deep Hidden Physics Model (DeepHPM) to discover the underlying governing dynamic models. The uncovered dynamics information is then fused with that mined by the surrogate neural network in the PINN framework. Moreover, an uncertainty-based adaptive weighting method is employed to balance the multiple learning tasks when training the PINN. The proposed methods are verified on a public dataset of Li-ion Phosphate (LFP)/graphite batteries.

In recent years, the Transformer architecture has shown its superiority in the video-based person re-identification task. Inspired by video representation learning, these methods mainly focus on designing modules to extract informative spatial and temporal features. However, they are still limited in extracting local attributes and global identity information, which are critical for the person re-identification task. In this paper, we propose a novel Multi-Stage Spatial-Temporal Aggregation Transformer (MSTAT) with two novel designed proxy embedding modules to address the above issue. Specifically, MSTAT consists of three stages to encode the attribute-associated, the identity-associated, and the attribute-identity-associated information from the video clips, respectively, achieving the holistic perception of the input person. We combine the outputs of all the stages for the final identification. In practice, to save the computational cost, the Spatial-Temporal Aggregation (STA) modules are first adopted in each stage to conduct the self-attention operations along the spatial and temporal dimensions separately. We further introduce the Attribute-Aware and Identity-Aware Proxy embedding modules (AAP and IAP) to extract the informative and discriminative feature representations at different stages. All of them are realized by employing newly designed self-attention operations with specific meanings. Moreover, temporal patch shuffling is also introduced to further improve the robustness of the model. Extensive experimental results demonstrate the effectiveness of the proposed modules in extracting the informative and discriminative information from the videos, and illustrate the MSTAT can achieve state-of-the-art accuracies on various standard benchmarks.

Non-line-of-sight (NLOS) imaging aims to reconstruct the three-dimensional hidden scenes from the data measured in the line-of-sight, which uses photon time-of-flight information encoded in light after multiple diffuse reflections. The under-sampled scanning data can facilitate fast imaging. However, the resulting reconstruction problem becomes a serious ill-posed inverse problem, the solution of which is of high possibility to be degraded due to noises and distortions. In this paper, we propose two novel NLOS reconstruction models based on curvature regularization, i.e., the object-domain curvature regularization model and the dual (i.e., signal and object)-domain curvature regularization model. Fast numerical optimization algorithms are developed relying on the alternating direction method of multipliers (ADMM) with the backtracking stepsize rule, which are further accelerated by GPU implementation. We evaluate the proposed algorithms on both synthetic and real datasets, which achieve state-of-the-art performance, especially in the compressed sensing setting. All our codes and data are available at https://github.com/Duanlab123/CurvNLOS.

Masked image modeling (MIM) has shown great promise for self-supervised learning (SSL) yet been criticized for learning inefficiency. We believe the insufficient utilization of training signals should be responsible. To alleviate this issue, we introduce a conceptually simple yet learning-efficient MIM training scheme, termed Disjoint Masking with Joint Distillation (DMJD). For disjoint masking (DM), we sequentially sample multiple masked views per image in a mini-batch with the disjoint regulation to raise the usage of tokens for reconstruction in each image while keeping the masking rate of each view. For joint distillation (JD), we adopt a dual branch architecture to respectively predict invisible (masked) and visible (unmasked) tokens with superior learning targets. Rooting in orthogonal perspectives for training efficiency improvement, DM and JD cooperatively accelerate the training convergence yet not sacrificing the model generalization ability. Concretely, DM can train ViT with half of the effective training epochs (3.7 times less time-consuming) to report competitive performance. With JD, our DMJD clearly improves the linear probing classification accuracy over ConvMAE by 5.8%. On fine-grained downstream tasks like semantic segmentation, object detection, etc., our DMJD also presents superior generalization compared with state-of-the-art SSL methods. The code and model will be made public at https://github.com/mx-mark/DMJD.