噪声的去除或取消对成像和声学具有广泛的应用。在日常生活中，Denoising甚至可能包括对地面真理不忠的生成方面。但是，对于科学应用，denoing必须准确地重现地面真相。在这里，我们展示了如何通过深层卷积神经网络来定位数据，从而以定量精度出现弱信号。特别是，我们研究了晶体材料的X射线衍射。我们证明，弱信号是由电荷排序引起的，在嘈杂的数据中微不足道的信号，在DeNo的数据中变得可见和准确。通过对深度神经网络的监督培训，具有成对的低噪声数据，可以通过监督培训来实现这一成功。这样，神经网络就可以了解噪声的统计特性。我们证明，使用人造噪声（例如泊松和高斯）不会产生这种定量准确的结果。因此，我们的方法说明了一种实用的噪声过滤策略，可以应用于具有挑战性的获取问题。

The future of population-based breast cancer screening is likely personalized strategies based on clinically relevant risk models. Mammography-based risk models should remain robust to domain shifts caused by different populations and mammographic devices. Modern risk models do not ensure adaptation across vendor-domains and are often conflated to unintentionally rely on both precursors of cancer and systemic/global mammographic information associated with short- and long-term risk, respectively, which might limit performance. We developed a robust, cross-vendor model for long-term risk assessment. An augmentation-based domain adaption technique, based on flavorization of mammographic views, ensured generalization to an unseen vendor-domain. We trained on samples without diagnosed/potential malignant findings to learn systemic/global breast tissue features, called mammographic texture, indicative of future breast cancer. However, training so may cause erratic convergence. By excluding noise-inducing samples and designing a case-control dataset, a robust ensemble texture model was trained. This model was validated in two independent datasets. In 66,607 Danish women with flavorized Siemens views, the AUC was 0.71 and 0.65 for prediction of interval cancers within two years (ICs) and from two years after screening (LTCs), respectively. In a combination with established risk factors, the model's AUC increased to 0.68 for LTCs. In 25,706 Dutch women with Hologic-processed views, the AUCs were not different from the AUCs in Danish women with flavorized views. The results suggested that the model robustly estimated long-term risk while adapting to an unseen processed vendor-domain. The model identified 8.1% of Danish women accounting for 20.9% of ICs and 14.2% of LTCs.

Predicting the future development of an anatomical shape from a single baseline is an important but difficult problem to solve. Research has shown that it should be tackled in curved shape spaces, as (e.g., disease-related) shape changes frequently expose nonlinear characteristics. We thus propose a novel prediction method that encodes the whole shape in a Riemannian shape space. It then learns a simple prediction technique that is founded on statistical hierarchical modelling of longitudinal training data. It is fully automatic, which makes it stand out in contrast to parameter-rich state-of-the-art methods. When applied to predict the future development of the shape of right hippocampi under Alzheimer's disease, it outperforms deep learning supported variants and achieves results on par with state-of-the-art.

We analyze the problem of detecting tree rings in microscopy images of shrub cross sections. This can be regarded as a special case of the instance segmentation task with several particularities such as the concentric circular ring shape of the objects and high precision requirements due to which existing methods don't perform sufficiently well. We propose a new iterative method which we term Iterative Next Boundary Detection (INBD). It intuitively models the natural growth direction, starting from the center of the shrub cross section and detecting the next ring boundary in each iteration step. In our experiments, INBD shows superior performance to generic instance segmentation methods and is the only one with a built-in notion of chronological order. Our dataset and source code are available at http://github.com/alexander-g/INBD.

This paper presents a two-step algorithm for online trajectory planning in indoor environments with unknown obstacles. In the first step, sampling-based path planning techniques such as the optimal Rapidly exploring Random Tree (RRT*) algorithm and the Line-of-Sight (LOS) algorithm are employed to generate a collision-free path consisting of multiple waypoints. Then, in the second step, constrained quadratic programming is utilized to compute a smooth trajectory that passes through all computed waypoints. The main contribution of this work is the development of a flexible trajectory planning framework that can detect changes in the environment, such as new obstacles, and compute alternative trajectories in real time. The proposed algorithm actively considers all changes in the environment and performs the replanning process only on waypoints that are occupied by new obstacles. This helps to reduce the computation time and realize the proposed approach in real time. The feasibility of the proposed algorithm is evaluated using the Intel Aero Ready-to-Fly (RTF) quadcopter in simulation and in a real-world experiment.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

荆棘冠的海星（婴儿床）爆发是珊瑚损失的主要原因是巨大的障碍礁（GBR），并且正在进行大量监测和控制计划，以试图管理生态可持续水平的COTS群体。我们释放了GBR上的COTS爆发区域的大规模注释的水下图像数据集，以鼓励机器学习和AI驱动技术的研究，以改善珊瑚礁秤上的COTS群体的检测，监测和管理。该数据集发布并托管在一次竞争中，挑战国际机器学习界，并从这些水下图像中的COTS检测的任务挑战。

最近应用于从密集护理单位收集的时间序列的机器学习方法的成功暴露了缺乏标准化的机器学习基准，用于开发和比较这些方法。虽然原始数据集（例如MIMIC-IV或EICU）可以在物理体上自由访问，但是选择任务和预处理的选择通常是针对每个出版物的ad-hoc，限制出版物的可比性。在这项工作中，我们的目标是通过提供覆盖大型ICU相关任务的基准来改善这种情况。使用HirID数据集，我们定义与临床医生合作开发的多个临床相关任务。此外，我们提供可重复的端到端管道，以构建数据和标签。最后，我们提供了对当前最先进的序列建模方法的深入分析，突出了这种类型数据的深度学习方法的一些限制。通过这款基准，我们希望为研究界提供合理比较的可能性。

本文提供了一个完整的管道，用于学习移动机器人的连续运动控制策略，只有可用的机器人 - 泰林相互作用的非差异物理模拟器才能提供。机器人的多模式状态估计也很复杂且难以模拟，因此我们同时学习了一个生成模型，该模型可以完善模拟器输出。我们提出了一个粗到精细的学习范式，其中粗略的运动计划与模仿学习和政策转移到真正的机器人。该政策通过生成模型共同优化。我们在一批实验中评估了现实世界平台上的方法。

本文提出了一种新颖的技术，该技术允许对具有不可构造轨道的车辆进行计算快速且足够合理的模拟。该方法基于我们称为接触表面运动的效果。提出了与其他几种模拟轨道车辆动力学模拟的方法的比较，目的是评估现成的方法或在通用机器人模拟器中使用最少努力的方法。提出的方法是使用开放动力学引擎的开源物理模拟器凉亭实现的。